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Ovalocytoses
Ovalocytoses


Blood cells
Blood cells


Hereditary ovalocytosis

Definition:

Hereditary ovalocytosis is rare condition passed down through families (inherited) in which blood cells are slightly oval-shaped instead of round. It is a form of hereditary elliptocytosis .



Alternative Names:

Ovalocytosis - hereditary



Causes, incidence, and risk factors:

Ovalocytosis is mainly found in Southeast Asian populations.



Symptoms:

Newborn infants with ovalocytosis may have anemia and jaundice. Adults usually do not show symptoms and are known as asymptomatic.



Signs and tests:

An examination by your health care provider may occasionally show an enlarged spleen.

This condition is diagnosed by looking at the shape of blood cells under a microscope. The following tests may also be done:

  • Complete blood count (CBC) to check for anemia or red blood cell destruction
  • Blood smear to determine cell shape
  • Bilirubin level (may be high)
  • Lactate dehydrogenase level (may be high)
  • Ultrasound of the abdomen (may show gallstones)


Treatment:

In severe cases, the disease may be treated by removal of the spleen (splenectomy ).



Support Groups:



Expectations (prognosis):



Complications:

The condition may be associated with gallstones or kidney problems.



Calling your health care provider:



Prevention:



References:

Golan DE. Hemolytic anemias: red cell membrane and metabolic defects. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 165.




Review Date: 2/5/2010
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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