Gout is caused by increased production of uric acid. Uric acid crystals travel and accumulate in the joints, especially in the feet and legs, causing great pain and swelling.
Gordon A. Starkebaum, MD, Professor of Medicine, Division of Rheumatology, University of Washington School of Medicine. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, Bethanne Black, Stephanie Slon, and Nissi Wang.